Visual Basic Quickstart
Step 1: Install the ScottPlot NuGet package
Step 2: Plot some data and save the figure as an image file
Dim xs = New Double() { 1, 2, 3, 4, 5 }
Dim ys = New Double() { 1, 4, 9, 16, 25 }
Dim plt = New ScottPlot.Plot()
plt.Add.Scatter(xs, ys)
plt.SavePng("quickstart.png", 600, 400)

Visual Basic Windows Forms App
Step 1: Install the ScottPlot.WinForms NuGet package
Step 2: Drag a FormsPlot control from the toolbox onto your Form
Step 3: Plot some data and call the control’s Refresh() method
Public Class Form1
Public Sub New()
InitializeComponent()
Dim xs = New Double() { 1, 2, 3, 4, 5 }
Dim ys = New Double() { 1, 4, 9, 16, 25 }
FormsPlot1.Plot.Add.Scatter(xs, ys)
FormsPlot1.Refresh()
End Sub
End Class

Visual Basic WPF App
Install the ScottPlot.WPF NuGet package then modify your code to resemble the following:
<Window x:Class="MainWindow"
xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation"
xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml"
xmlns:d="http://schemas.microsoft.com/expression/blend/2008"
xmlns:mc="http://schemas.openxmlformats.org/markup-compatibility/2006"
xmlns:local="clr-namespace:WpfApp12"
xmlns:ScottPlot="clr-namespace:ScottPlot.WPF;assembly=ScottPlot.WPF"
mc:Ignorable="d"
Title="MainWindow" Height="450" Width="800">
<ScottPlot:WpfPlot x:Name="WpfPlot1" />
</Window>
Class MainWindow
Private Sub Window_Loaded(sender As Object, e As RoutedEventArgs) Handles Me.Loaded
Dim xs = New Double() {1, 2, 3, 4, 5}
Dim ys = New Double() {1, 4, 9, 16, 25}
WpfPlot1.Plot.Add.Scatter(xs, ys)
WpfPlot1.Plot.Axes.AutoScale()
WpfPlot1.Refresh()
End Sub
End Class